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KMID : 0043319880110040301
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Archives of Pharmacal Research
1988 Volume.11 No. 4 p.301 ~ p.307
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The Relationship between Hypertension and Central Serotonergic Nervous System Activity in Spontaneously Hypertensive Rats
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Kim SJ
Ko KH
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Abstract
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Relationship between the maintenance of hypertension and central serotonergic nervous system activity in spontaneously hypertensive rats (SHR) was studied. Serotonin turnover-rates were measured in 5 brain areas as an index of serotonergic neuronal activity and compared at the ages of 14 weeks in two types of animals; (1) spontaneously hypertensive rats (SHR) (2) normotensive wistar kyoto rats (WKY). In 14-week old SHR, central serotonin turnover rate was significantly lower in telencephalon, hypothalamus/thalamus and midbrain than normotensive rat, but significantly higher in cerebellum. There were no significant differences between serotonin turnover rate in pons/medulla of SHR and that of normotensive rat. These data suggest that the abnormally lower turnover rates of serotonin in telencephalon, hypothalamus/thalamus and midbrain may be one of the underlying neuronal factors for manifestation of hypertension in SHR.
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KEYWORD
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